SYSTEMS AND METHODS FOR ACCELERATED HYDROLYSIS OF POLYSACCHARIDE-BASED HYDROGELS

Abstract: in some aspects, the present disclosure provides kits for delivering and hydrolyzing crosslinked polysaccharide hydrogels, the kits comprising (a) a hydrogel delivery system configured to deliver a crosslinked polysaccharide hydrogel to a subject, the crosslinked polysaccharide hydrogel comprising polysaccharide molecules that are crosslinked by crosslinks that comprise hydrolysable ester bonds and (b) a hydrogel hydrolysis system configured to deliver a hydrolysis-accelerating catalytic composition to the subject, the hydrolysis-accelerating catalytic composition adapted to accelerate hydrolysis of the hydrolysable ester bonds in the crosslinked polysaccharide hydrogel. in other aspects, the present disclosure provides methods of using the same.

Inventor(s): Yen-Hao Hsu, Heather Cirka, Marc Plourde, Cristian Parisi

CPC Classification: A61K9/06 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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