Intestinal-targeted sustained-release of polyphenols and preparation method and application thereof

Abstract: the present invention belongs to the field of drug delivery and food and pharmaceutical technology, and specifically relates to resistant starch for intestinal-targeted sustained-release of polyphenols, and a preparation method and application thereof, comprising the following steps: preparing quinoa polyphenol extract; annealing and recrystallizing heat-dispersed high-amylose maize starch in an ethanol solution to obtain single-helix resistant maize starch; self-assembling single-helix resistant maize starch and quinoa polyphenol extract in an alcohol-water system to obtain intestinal-targeted sustained-release of polyphenol/resistant starch. the intestinal-targeted sustained-release of polyphenol/resistant starch prepared by the method of the present invention has a specific starch helical structure that can realize intestinal-targeted controlled release of polyphenols in the content, reduce the loss of phenolic compounds during gastrointestinal digestion, realize the precise and continuous release of polyphenol compounds in the intestinal digestion stage, and prolong the retention time of polyphenols in the intestine, thereby improving the bioavailability of polyphenols.

Inventor(s): Linglin FU, Qiaozhi Zhang, Shiyu Fan, Junfeng Yin, Zhengshun Wen, Yongguan Xu

CPC Classification: A61K9/0053 (Medicinal preparations characterised by special physical form {(nuclear magnetic resonance contrast preparations or magnetic resonance imaging contrast preparations ; preparations containing radioactive substances )})

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