20250228219. Genetically Modified Mo (The Jackson Laboratory)
GENETICALLY MODIFIED MOUSE MODELS OF ALZHEIMER’S DISEASE
Abstract: the present disclosure provides a genetically modified mouse comprising a genomic nucleic acid encoding human apoe4, a genomic nucleic acid encoding mouse trem2 modified to include a r47h substitution, and at least one genomic modification selected from the group consisting of: (a) a genomic nucleic acid encoding mouse abca7 modified to include an a 1541 g substitution; (b) a genomic nucleic acid encoding mouse app modified to include g60ir, f606y, and r609h substitutions; (c) a genomic nucleic acid encoding mouse plcg2 modified to include a m28l substitution; (d) a genomic nucleic acid encoding mouse mthfr modified to include a a262v substitution; (e) an inactivated ceacaml allele; and (f) an inactivated ii1rap allele. methods of producing the genetically modified mouse and methods of using the genetically modified mouse are also provided.
Inventor(s): Gareth Howell, Gregory Carter, Michael Sasner, Stacey Rizzo, Harriet Williams, Bruce Lamb, Paul Territo, Adrian Oblak, Ben Logsdon, Lara Mangravite, Leah Graham
CPC Classification: A01K67/0278 (New or modified breeds of vertebrates)
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- Patent Applications
- The Jackson Laboratory
- CPC A01K67/0278
- Gareth Howell of Bar Harbor ME US
- Gregory Carter of Bar Harbor ME US
- Michael Sasner of Bar Harbor ME US
- Stacey Rizzo of Bar Harbor ME US
- Harriet Williams of Bar Harbor ME US
- Bruce Lamb of Carmel IN US
- Paul Territo of Fishers IN US
- Adrian Oblak of Fishers IN US
- Ben Logsdon of Seattle WA US
- Lara Mangravite of Seattle WA US
- Leah Graham of Bar Harbor ME US