SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM FOR IDENTIFYING TARGET PAIRS FOR CAR-T THERAPY

Abstract: exemplary systems, methods, and computer-accessible medium are provided for chimeric antigen receptor (car)-t therapy. thus, the exemplary systems, methods, and computer-accessible medium are provided that select a first set of targets highly expressed in cancer and lowly in normal tissues, select a second set of targets that are highly co-expressed in the cancer and lowly in normal tissues, generate an input set by combining the first and second set of targets with dependency data, single-cell heterogeneity, and antibody availability, determine, by a learning model, at least one target pair for use in car-t therapy, and apply a cell therapy based on the determined target pair(s).

Inventor(s): MARK YARMARKOVICH, ZACHARY HARPAZ, GUANGYUAN LI, MICHELE PALAMENGHI

CPC Classification: G16H20/40 (relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture)

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