IDENTIFICATION, CHARACTERIZATION, AND QUANTITATION OF CRISPR-INTRODUCED DOUBLE-STRANDED DNA BREAK REPAIRS

Abstract: described herein is a system and process for identifying and characterizing double-stranded dna break repair sites that are based on biological information and have improved accuracy. also described is a sequence alignment process that uses biological data to inform the alignment matrix for position specific alignment scoring, resulting in the identification of noncanonical target sites.

Inventor(s): Heng Li, Gavin Kurgan, Matthew McNeill, Yu Wang

CPC Classification: G16B20/30 (BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY)

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