COMPOSITIONS AND METHODS FOR DETECTING CARDIOTOXICITY

Abstract: a method of screening a composition for cardiotoxicity comprising contacting the composition with cardiomyocytes that have increased fatty acid oxidation and/or diminished glucose oxidation. the cardiomyocytes are preferably prepared by overexpression of cox7a1. the cardiomyocytes are preferably provided in a micropatterned co-culture to provide a mature functional hpsc-cm cardiotoxicity model.

Inventor(s): Michael D. WEST, Jeffrey JANUS

CPC Classification: G01N33/5014 ({for testing toxicity})

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