ENANTIOSELECTIVE METHODS FOR PREPARING CHIRAL AMINE INTERMEDIATES

Abstract: a method for preparing chiral amines useful as pharmaceutical intermediates is provided. the method comprises contacting an ester of formula i in which ris a methyl or an ethyl group; ris a linear or branched c-calkyl group; and n is 0 or 1 with an enantioselective �-transaminase in the presence of an amino donor so that the �-transaminase catalyses the enantioselective transfer of an amino group from the amino donor to the �- or �-ketone group of the ester of formula i to produce an amino ester product with enantiomeric excess of a selected enantiomer.

Inventor(s): Daniel Petzer PIENAAR, Dean BRADY, Josephine Tshegofatso MABOYA

CPC Classification: C12P13/001 (FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {(brewing of beer ; producing vinegar ; producing specific peptides or proteins ; producing enzymes ; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification ; measuring or testing processes involving enzymes or microorganisms ; measuring or testing processes involving nucleic acid amplification reactions ; fermentation processes to form a food composition, or ; compounds in general, see the relevant compound class, e.g. , )})

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