ANTI-HELICASE THERAPY FOR TREATMENT OF REPEAT EXPANSION DISEASE

Abstract: provided herein is technology relating to treatment of diseases e.g. neurodegenerative diseases caused by repeat-associated non-aug translation of nucleotide repeat expansions and particularly, but not exclusively, to methods of treating disease by inhibiting dhx36 helicase by administering to the patient an inhibitor of dhx36 in order to provide an effective therapeutic intervention for treating pathogenesis related to the c9orf72 nucleotide repeat expansions.

Inventor(s): Jiou Wang, Honghe Liu

CPC Classification: C12N15/1137 ({against enzymes (viral enzymes ; receptors )})

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