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20250215417. Methods Separa (Ionis Pharmaceuticals, .)

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Methods for Separating Certain Oligonucleotide Compounds

Abstract: provided are methods for reducing the amount of a contaminant in a sample containing an oligomeric compound. the method may comprise chromatography using a mobile phase comprising a strong salt and a chaotrope. also provided are oligomeric compounds prepared by the method.

Inventor(s): Stilianos G. Roussis, Claus Andre Frank Rentel

CPC Classification: C12N15/101 ({by chromatography, e.g. electrophoresis, ion-exchange, reverse phase})

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