IMPROVED MACROMOLECULES AND METHODS FOR DESIGNING SAME

Abstract: the present invention is directed to, inter alia, a method for identifying a reference macromolecule for which a variant having improved function can be identified and/or engineered. further provided is a macromolecule variant, such as, but not limited to cas protein variant(s), being characterized by having improved function compared to a reference, and a method for designing same.

Inventor(s): Daniel OFFEN, Roy RABINOWITZ, Felix BENNINGER, Oded SHOR

CPC Classification: C12N9/22 (MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media ))

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