AUTOMATED QUALITY CONTROL AND ASEPTIC TRANSFERS IN A CELL PROCESSING SYSTEM

Abstract: the invention relates to a method and system for maintaining aseptic conditions and verifying filter integrity in a cell processing platform. the platform features an integrated pressure decay testing module to evaluate the functionality of hydrophilic and hydrophobic filters before and after processing. the system operates by pressurizing filters, measuring pressure decay, and determining integrity based on predefined thresholds, with results logged for compliance. the platform includes a cell processing cassette (cpc) equipped for sequential cell processing steps, such as washing, selection, activation, and harvesting, within a single chamber. automated fluid and gas transfer systems, incorporating filters and emergency recovery pathways, ensure contamination-free operations. additional features include uv disinfection, adaptive control systems for parameter optimization, and temperature-controlled environments to support cell viability. this comprehensive system enhances reliability, precision, and sterility in automated cell processing for advanced therapeutic applications.

Inventor(s): Philip H. Coelho, Duncan MacGregor, Paul Getchel, Jonathan Ellis

CPC Classification: C12M47/04 ({Cell isolation or sorting (purging biological preparations of unwanted cells , determining the presence or kind of microorganism )})

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