20250215382. Functionally Closed (Trenchant BioSystems, .)
FUNCTIONALLY CLOSED CELL PROCESSING SYSTEM
Abstract: a functionally closed cell processing platform designed to minimize contamination and automate cell processing. the platform integrates multiple specialized cassettes, including a reagent sample cassette (rsc) for reagent delivery and sample collection, a process fluids cassette (pfc) for waste and buffer management, and a cell processing cassette (cpc) for cell handling, along with a transfer syringe cassette (tsc) for precise fluid transfer. the system features a centrifuge capable of multi-mode operation for cell concentration and mixing, pneumatic controls for fluid and microbubble manipulation, and uv sanitizers to maintain aseptic conditions. advanced functionalities include optical and thermal sensors for real-time monitoring, automated control of fluid and reagent handling, and a microbubble cell selection system for precise target cell isolation. this innovative platform ensures efficient, contamination-free cell processing, supporting applications in gene therapy, cell manufacturing, and biomedical research.
Inventor(s): Philip H. Coelho, Paul Getchel, Jonathan Ellis, Benjamin T. Edmundson, Samuel G. Miller, Duncan MacGregor, Michael S. Wilk, Joël Bodenmann
CPC Classification: C12M41/48 ({Automatic or computerized control (automatic analysis )})
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- Patent Applications
- Trenchant BioSystems, Inc.
- CPC C12M41/48
- Philip H. Coelho of Sacramento CA US
- Paul Getchel of Fallon NV US
- Jonathan Ellis of Stockton CA US
- Benjamin T. Edmundson of Orangeville CA US
- Samuel G. Miller of Folsom CA US
- Duncan MacGregor of Shingle Springs CA US
- Michael S. Wilk of Rocklin CA US
- Joël Bodenmann of Seewjinenstrasse CH