OPTIMIZED GEOMETRIC DESIGN OF A CELL PROCESSING CASSETTE

Abstract: the disclosed invention presents the autocell platform (acp), an advanced, fully automated, and functionally closed system designed to revolutionize the manufacturing of gene-modified cell therapies. this innovative platform integrates automation, closed-loop processing, and novel technologies to address the inefficiencies and high costs of conventional methods. key features include automated spinoculation for enhanced genetic modification efficiency, microbubble-assisted cell selection for precise cell isolation, and modular design for scalability across clinical and research settings. by reducing production timelines from 30-40 days to under 3 days and lowering costs by an order of magnitude, the acp enables point-of-care manufacturing, decentralization, and broader accessibility. advanced quality control measures and a standardized design ensure regulatory compliance and consistent therapeutic outcomes. the acp supports diverse applications, from car-t therapies to regenerative medicine, representing a transformative leap in precision medicine and the global accessibility of life-saving cell-based therapies.

Inventor(s): Philip H. Coelho, Paul Getchel, Jonathan Ellis

CPC Classification: C12M41/36 ({of biomass, e.g. colony counters or by turbidity measurements (electrooptical investigation of individual particles , flow cytometers )})

Search for rejections for patent application number 20250215380