ACTIVATABLE MULTISPECIFIC MOLECULES AND METHODS OF USE THEREOF

Abstract: activatable proteins comprising a first target binding protein (tb1) that specifically binds to a first target; a second target binding protein (tb2) that specifically binds to a second target, wherein the tb2 is directly or indirectly coupled to the tb1; a first masking moiety (mm1) inhibiting the binding of the tb1 to the first target and coupled to the tb1 via a cleavable moiety, directly or indirectly, e.g., via one or more linkers or other components; a second masking moiety (mm2) inhibiting the binding of the tb2 to the second target and coupled either to the tb1 or to the tb2 via a cleavable moiety, directly or indirectly; and a half-life extending moiety (em) coupled either to the tb1 or to the tb2 via a cleavable moiety, directly or indirectly. the activatable proteins are configured such that when the cleavable moieties are cleaved, the resulting activated protein has a shorter half life, a higher binding affinity for the first target, and a higher binding affinity for the second target as compared to the intact activatable protein.

Inventor(s): Madan M. PAIDHUNGAT, Sayantan MITRA, Ellaine Anne Mariano FOX, Veena VINOD, Sonali Arun PATIL, Leila M. BOUSTANY

CPC Classification: C07K16/32 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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