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20250215109. Anti-her2/anti- (Wuxi Biologics Ireland Limited)

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ANTI-HER2/ANTI-CD47 MOLECULES AND USES THEREOF

Abstract: provided herein are anti-cd47/anti-her2 polypeptide complexes, nucleic acid molecules encoding the variable domains of the polypeptide complexes, expression vectors and host cells used for the expression of the polypeptide complexes. the disclosure further provides methods for producing the polypeptide complexes and uses thereof.

Inventor(s): Siwei NIE, Jiaxiang SHAO, Qin MEI, Fagen HU, Jianqing XU, Shuang WANG, Jijie GU, Yuhong SHEN, Zhijian CHEN, John Fenyu JIN, Haopeng RUI

CPC Classification: C07K16/32 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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