ANTIGEN BINDING PROTEIN TARGETING CD40, AND PREPARATION THEREFOR AND USE THEREOF

Abstract: disclosed in the present invention are an antigen binding protein targeting cd40, and the preparation therefor and the use thereof. the antigen binding protein targeting cd40 has the characteristics of a high affinity to cd40 and a strong agonistic activity on signaling pathways, particularly the enhanced agonistic activity after crosslinking, so that the antigen binding protein targeting cd40 has a larger therapeutic window, and is expected to bring about new opportunities for the treatment of various tumors.

Inventor(s): Haishan LUO, He LI, Gang DENG, Yongqiang WANG, Yuandong WANG, Fei CHEN, Yiping RONG

CPC Classification: C07K16/2878 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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