Human Epidermal Growth Factor Receptor Binding Molecule and Use Thereof

Abstract: provided in the present invention are a human epidermal growth factor receptor binding molecule and the use thereof. the human epidermal growth factor receptor binding molecule of the present invention contains a single domain antibody, which is against the human epidermal growth factor receptor. a complementary determining region (cdr) of the single domain antibody comprises cdr1, as represented by seq id no: 1, cdr2, as represented by seq id no: 2, and cdr3, as represented by seq id no: 3. also provided in the present invention are a polynucleotide encoding the binding molecule, a nucleic acid construct containing same, and a corresponding phage, host cell, pharmaceutical composition, production method and non-diagnostic method, and the corresponding use.

Inventor(s): Jiaguo LI, Xiangzhen LIU, Weimin ZHU, Yan SUN, Na DING, Qijun QIAN

CPC Classification: C07K16/2863 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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