VARIANT CH3 DOMAINS ENGINEERED FOR PREFERENTIAL CH3 HETERODIMERIZATION, MULTI-SPECIFIC ANTIBODIES COMPRISING THE SAME, AND METHODS OF MAKING THEREOF

Abstract: variant ch3 domain polypeptides are provided that preferentially form ch3-ch3 heterodimers over ch3-ch3 homodimers. such variant ch3 domains can be used to promote desired fc pairing, thus providing for efficient development of bispecific and multispecific antibodies as well as fc fusions of different formats. methods of producing bispecific antibodies using such variant ch3 domains and for producing libraries containing such variant ch3 domains are also provided.

Inventor(s): Caitlin STEIN, Robert PEJCHAL, Julia MCCREARY, Kyle BARLOW, Arvind SIVASUBRAMANIAN, Michael Benjamin BATTLES, Beth H. SHARKEY

CPC Classification: C07K16/2809 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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