MONOVALENT ANTI-TREM2 BINDING MOLECULES AND METHODS OF USE THEREOF

Abstract: in one aspect, monovalent binding molecules that specifically bind to a human triggering receptor expressed on myeloid cells 2 (trem2) protein are provided, as well as methods of use thereof.

Inventor(s): Mark S. DENNIS, Gilbert DI PAOLO, Anuja R. MODI, Kathryn M. MONROE, Adam P. SILVERMAN, Bettina VAN LENGERICH, Lihong ZHAN

CPC Classification: C07K16/2803 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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