ANTIBODY FRAGMENT SPECIFIC TO C-KIT POSITIVE TUMORS

Abstract: an object of the present invention is to provide a detection agent (diagnostic agent) and a treatment agent targeting c-kit molecules, which are taken up into tumors early in vivo. as a result of examining a molecular species that specifically binds to c-kit and a labeling agent and a treatment agent which are coupled to the molecular species, the inventors found that combining an anti-c-kit antibody fragment and ir700 makes it possible to accumulate the combined product in a tumor for a short period, such as several hours from administration for detecting and treating the tumor. therefore, the present invention relates to a complex of the antigen-binding fragment of an anti-c-kit antibody and ir700 and also relates to a detection agent and a treatment agent containing the complex as an active ingredient. specifically, the present invention relates to a complex comprising: an antigen-binding fragment of an antibody having a complementarity determining region (cdr) in an antibody heavy chain having an amino acid sequence set forth in seq id no: 2 and a cdr in an antibody light chain having an amino acid sequence set forth in seq id no: 4; and ir700.

Inventor(s): Tsutomu SEITO, Tatsuya SEGAWA, Mamoru SHIMIZU, Tetsuji TAKAYAMA, Naoki MUGURUMA, Shota FUJIMOTO, Takanori KASHIHARA

CPC Classification: C07K16/24 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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