BISPECIFIC T CELL ENGAGER AND USES THEREOF

Abstract: a novel fusion protein to overcome the current difficulties related to application of monoclonal antibodies in disease treatment and in other fields, particularly those requiring adcc, e.g. for depletion of tumor cells, virally-infected cells, or immune-modulating cells, etc. one example of the fusion protein is an extracellular domain of a high-affinity variant of human cd 16 a fused to an anti-cd3 antibody or its antigen-binding fragment thereof that specifically binds to an epitope on human cd3 or a fragment thereof.

Inventor(s): HSIN-YI HUANG, CHENG HAO LIAO, CHUN-MING LIN

CPC Classification: C07K14/70535 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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