COMPOSITIONS AND METHODS FOR TREATMENT OF FUNGAL INFECTIONS

Abstract: novel peptide analogs of a �-defensin have been developed that provide a biphasic effect in treating disseminated fungal disease and/or associated septic shock. these analogs are active at concentrations below those needed to provide a fungicidal effect, and function by initially mobilizing effector cells of the immune system to address the infective organism followed by regulation of the immune system to down regulate the inflammatory response. these novel �-defensin analogs are protective at concentrations where naturally occurring �-defensins have no apparent effect, and include a core set of structural and sequence features not found in native �-defensins.

Inventor(s): Michael E. Selsted, Dat Q. Tran, Justin B. Schaal, Virginia Basso

CPC Classification: C07K7/64 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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