Compounds and Methods for Inhibiting LPA

Abstract: provided are oligomeric duplexes, oligomeric compounds and antisense agents, methods, and pharmaceutical compositions for reducing the amount or activity of lpa rna in a cell or animal, and in certain instances reducing the amount of lp(a) in a subject. such oligomeric duplexes, oligomeric compounds and agents, methods, and pharmaceutical compositions are useful to treat or manage inflammatory, cardiovascular and/or metabolic diseases, disorders, or conditions.

Inventor(s): Dieter Kubli, Adam Mullick, Thazha P. Prakash, Eric E. Swayze

CPC Classification: C07H21/04 (SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS (derivatives of aldonic or saccharic acids , ; aldonic acids, saccharic acids , ; cyanohydrins ; glycals ; compounds of unknown constitution ; polysaccharides, derivatives thereof ; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification ; sugar industry ))

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