System and Method for Aqueous Conjugation of Substrates Using Diels-Alder Chemistry

Abstract: a method for conjugating oligonucleotides to bead supports includes adding 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methyl-morpholinium to an aqueous suspension including bread supports having carboxy functional groups; adding amino-maleimide to the aqueous suspension; and adding diene modified oligonucleotide to the aqueous suspension.

Inventor(s): Dong Li, Amneet Gulati

CPC Classification: C07H21/00 (Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids)

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