FORMATION OF N-PROTECTED 3,6-BIS-(4-AMINOBUTYL)-2,5-DIKETOPIPERAZINE THROUGH A CYCLIC ALPHA-N-PROTECTED AMINO ESTER INTERMEDIATE

Abstract: a method for the synthesis of n-protected 3,6-aminoalkyl-2,5-diketopiperazines is provided. the method includes obtaining a cyclic �-n protected active amino ester and adding it to a mixture of an amine catalyst in an organic solvent.

Inventor(s): JOHN J. FREEMAN, OTTO PHANSTIEL, WILLIAM ELLIOT BAY, KELLY SULLIVAN KRAFT

CPC Classification: C07D241/08 (HETEROCYCLIC COMPOUNDS (macromolecular compounds ))

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