METHOD FOR PRODUCING ARYL ESTER-CONTAINING CARBOXYLIC ACID AND METHOD FOR PRODUCING CATIONIC LIPID

Abstract: the present invention provides a method for producing a high-purity carboxylic acid containing aryl ester that suppresses generation of oligomers and does not require a purification step with low productivity such as column chromatography and the like, and a method for producing cationic lipids. a method for producing an aryl ester-containing carboxylic acid (), including the following steps: 1) a step of reacting a compound () using potassium tert-butoxide and tert-butyl alcohol in the presence of an aprotic solvent to obtain a compound (), 2) a step of reacting the compound () with a compound () using a condensing agent to obtain a compound (), and 3) a step of deprotecting the tert-butyl group of the compound () by using trifluoromethanesulfonic acid, methanesulfonic acid, a combination of tms-cl and sodium iodide, or tms-i in an organic solvent to obtain the compound () (a is phenyl having —o—c(═o)rgroup, etc., and b is phenyl having hydroxy group, etc.).

Inventor(s): Ryosuke Motousu, Masaki Ota, Daiki Ozone, Masayuki Sato

CPC Classification: C07D211/24 (HETEROCYCLIC COMPOUNDS (macromolecular compounds ))

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