AUTOMATIC BALANCING SYSTEM FOR A CENTRIFUGE SYSTEM

Abstract: an automatic balancing system for a centrifuge designed to maintain stability and minimize vibration during rotation. the system incorporates a central rotor with radially aligned linear actuators to adaptively counterbalance variations in fluid volume and weight distribution within cell processing cassettes (cpcs). it features accelerometers and position sensors for real-time monitoring and adjustment, with a user interface enabling automated or manual optimization of counterbalance weights. additional innovations include radar-based fluid-level sensing for precise weight estimations, advanced optical detection systems for monitoring cell sedimentation, and a centrifuge control module to adjust rotational speed based on cell density feedback. the system also includes a temperature regulation mechanism, locking actuators, and multi-spectral imaging capabilities for enhanced processing accuracy. this comprehensive platform ensures precise, efficient, and contamination-free operations for automated cell processing applications, including gene therapy and therapeutic cell production.

Inventor(s): Philip H. Coelho, Paul Getchel, Jonathan Ellis, Benjamin T. Edmundson, Samuel G. Miller, Duncan MacGregor, Michael S. Wilk, Joël Bodenmann

CPC Classification: B04B9/146 (CENTRIFUGES (high-speed drum mills ; domestic spin driers ; analysing, measuring or monitoring physical or chemical properties of samples during centrifuging, see the relevant subclasses for these procedures, e.g. ))

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