SYSTEMS AND METHODS FOR CHROMATOGRAPHY USE AND REGENERATION

Abstract: aspects of the present disclosure relate to a method of regenerating a hydrophobic interaction chromatography column to which a load mass has been applied, the method comprising passing one or more column volumes of an alkaline solution through hydrophobic interaction media within the column, wherein the alkaline solution exhibits a ph of between about 10 and about 14, and a conductivity of between 0.5 ms/cm and about 10 ms/cm, wherein material bound to the hydrophobic interaction media is removed. in some cases, the alkaline solution may include sodium hydroxide at a concentration of between, e.g., about 0.1 mm and 10 mm.

Inventor(s): Robert STAIRS, James REILLY, John MATTILA, Samantha WADSWORTH

CPC Classification: B01J20/3475 (CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS)

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