PROTEASE-CLEAVABLE SUBSTRATES AND METHODS OF USE THEREOF

Abstract: isolated polypeptides that include a cleavable moiety that is a substrate for at least two proteases (e.g., mt-sp1 and an mmp) are disclosed. activatable molecules including the isolated polypeptides are disclosed. methods of making and using the isolated polypeptides and activatable molecules including the isolated polypeptides in a variety of therapeutic, diagnostic, and prophylactic applications are disclosed.

Inventor(s): Olga VASILJEVA, Michael B. WINTER

CPC Classification: A61K47/6889 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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