COMPOUNDS, COMPOSITIONS, AND METHODS FOR CELL-SPECIFIC PHARMACOLOGY

Abstract: disclosed herein are compounds that have improved cellular specificity. the compounds have linkers and other moieties that can both aid in cellular specificity and that can attach functional groups to a target cell. the compounds can be used, e.g., in methods of modulating, detecting, and labeling of proteins and cells. an example method includes the compound forming a covalent bond with a dehalogenase variant.

Inventor(s): Michael Tadross, Allen B. Reitz, Mark McConnell, Marie Loughran

CPC Classification: A61K47/55 (the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds)

Search for rejections for patent application number 20250213700