COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING CYTOKINE RELEASE SYNDROME

Abstract: compositions and methods are provided that are useful for treating or preventing cytokine release syndrome, which is a major cause of deaths in infections with virulent viruses such as the coronaviruses and influenza viruses. therapies such as immunomodulators and car-t have also been associated with cytokine release syndrome. the treatment includes the administration of a syk inhibitor or a pharmaceutically acceptable salt thereof. preferably a dual syk/jak inhibitor or a pharmaceutically acceptable salt thereof.

Inventor(s): Pamela B. Conley, Gregory Coffey, Matthew Birrell

CPC Classification: A61K31/506 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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