T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING A PIPERAZINE OR 1,4-DIAZEPANE CORE AND METHODS OF USE THEREOF

Abstract: disclosed herein are compounds for treating a condition modulated by calcium channel ion activity and pharmaceutical compositions comprising the compounds, including the compounds comprising a piperazine core, a 1,4-diazepane core or a 1,5-diazepane core. also disclosed herein are methods using the compounds to treat a disease or condition relating to aberrant function or activity of a t-type calcium channel.

Inventor(s): Ricardo Lira, Hamish Toop, Andrew Mark Griffin, Jon Sutton, Lampros Milanos

CPC Classification: A61K31/4995 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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