Ionic Liquid-Incorporated Lipid Nanoparticles

Abstract: the present invention is an improvement in lipid nanoparticles (lnps) for re-routing their distribution from the liver and spleen (the non-target organs) to hard-to-deliver targets such as the brain and other tissues for drug delivery. specifically, the invention derivatizes or otherwise modifies lnps to provide the surface or constituency thereof with “ionic liquid” (il) so that the il-lnp incorporates an ionizable lipid such as a cationic ionizable lipid, an optional helper lipid, cholesterol and a (true) ionic liquid component. among other benefits of the inclusion of “ionic liquid” is to decrease the delivery of lnps to the body's filtering organ—the liver—and thereby re-route delivery to other target organs.

Inventor(s): Purva Prasad Khare, Eden E.L. Tanner, Devika Soundara Manickam

CPC Classification: A61K9/1272 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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