COMPOSITIONS AND METHODS

Abstract: the disclosure provides, inter alia, dual-layer, semi-permeable, fibrosis-resistant, hydrogel polymer enclosures, optionally containing cells, such as mammalian cells, where the enclosures are suitable for administration to a subject in need thereof and further wherein the enclosure are scalable for large volumes of delivered cells. the disclosure further provides methods of making and using the enclosures, for example, in therapeutic methods, such as treating disorders of the liver or other cells and organs treatable with, for example secretory and/or catalytic cells.

Inventor(s): Ayse Jane MUNIZ, Matthew Dean ABBINANTI, Christopher Glen RAMSBORG, Fabiana ZAPPALA, Patrick Robert LUNDGREN

CPC Classification: A61K9/06 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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