PATHOGEN-RESISTANT ANIMALS HAVING MODIFIED CD163 GENES

Abstract: non-human animals and offspring thereof comprising at least one modified chromosomal sequence in a gene encoding a cd163 protein are provided. animal cells that contain such modified chromosomal sequences are also provided. the animals and cells have increased resistance to pathogens, including porcine reproductive and respiratory syndrome virus (prrsv). the animals and offspring have chromosomal modifications of a cd163 gene. the invention further relates to methods of breeding to create pathogen-resistant animals and populations of animals made using such methods.

Inventor(s): Randall S. Prather, Kevin D. Wells, Kristin M. Whitworth

CPC Classification: A01K67/0276 (New or modified breeds of vertebrates)

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