ASPERGILLUS SP. L14-OE::LAEA2 AND APPLICATION THEREOF IN PRODUCING CYCLIC TRIPEPTIDES

Abstract: an application method includes: applying an sp. l14-oe::laea2 in producing cyclic tripeptides. in the cyclic tripeptides obtained by separating and purifying a fermented product of the sp. l14-oe::laea2, a yield of aspochracin is 175 mg/l, a yield of jbir-15 is 100 mg/l, and a yield of sclerotiotide c is 25 mg/l. the yields of the compounds are significantly higher than those reported in other literature, and a separation process of obtaining the compounds is simple and economical. the cyclic tripeptides may be used to prepare drugs with antifungal activity and antioxidants activity, and for inhibiting activity of tumor cells and anti-tumor drugs. at a concentration of 10 �m, the jbir-15 has an inhibition rate of 11.78% on a human hepatocellular carcinoma cell line (hep-g2), and the sclerotiotide c has an inhibition rate of 21.09% on a human hepatocellular carcinoma cell line (hep-g2).

Inventor(s): Huawei Zhang, Mengshi Li, Zhiyang Fu, Huawei Lv

CPC Classification: C12P21/00 (Preparation of peptides or proteins (single cell protein ))

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