CEACAM5-DEPENDENT 4-1BB-AGONISTIC BISPECIFIC ANTIBODIES

Abstract: provided are bispecific or multispecific antibodies that include an anti-ceacam5 portion and one or more anti-4-1bb nanobodies whose agonist activity is dependent on the presence of the ceacam5 antigen. such bispecific or multispecific antibodies are safe, and are efficacious in treating cancer and have long-term protective immunological memory against tumors. methods of using the antibodies for treating diseases such as cancer are also provided.

Inventor(s): Runsheng Li, Wei Cao, Ying Qin Zang, Wentao Huang

CPC Classification: C07K16/2878 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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