HIGH AFFINITY ANTIBODIES TO HUMAN IL-6 RECEPTOR

Abstract: a human antibody or an antigen-binding fragment which binds human il-6 receptor (hil-6r) with a kof about 500 pm or less and blocks il-6 activity with an icof 200 pm or less, is provided. in preferred embodiments, the antibody the antibody or antigen-binding fragment binds hil-6r with an affinity at least 2-fold higher relative to its binding monkey il-6r.

Inventor(s): Sean Stevens, Tammy T. Huang, Joel H. Martin, Jeanette L. Fairhurst, Ashique Rafique, Eric Smith, Kevin J. Pobursky, Nicholas J. Papadopoulos, James P. Fandl, Gang Chen, Margaret Karow

CPC Classification: C07K16/2866 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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