DEIMMUNIZED ANTIBODIES SPECIFIC FOR CD3

Abstract: the present invention provides affinity optimized and deimmunized human antibodies that specifically bind to cd3. the present disclosure also provides bispecific antibodies comprising the optimized human antibodies e.g. for activating of t cells. the invention further relates to methods of generating the human antibodies and methods of using them in the treatment of diseases.

Inventor(s): Markus MOOSMEIER, Andreas BÜLTMANN, Steffen RUNZ

CPC Classification: C07K16/2809 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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