POLYNUCLEOTIDES ENCODING APOA-1 FUSION POLYPEPTIDES

Abstract: compositions and methods relating to apoa-1 fusion polypeptides are disclosed. the fusion polypeptides include a first polypeptide segment corresponding to an apoa-1 polypeptide or apoa-1 mimetic, and may also include a dimerizing domain such as, e.g., an fc region, which is typically linked carboxyl-terminal to the first polypeptide segment via a flexible linker. in some embodiments, the fusion polypeptide further includes a second polypeptide segment located carboxyl-terminal to the first polypeptide segment and which confers a second biological activity (e.g., an rnase, paraoxonase, platelet-activating factor acetylhydrolase, cholesterol ester transfer protein, lecithin-cholesterol acyltransferase, polypeptide that specifically binds to proprotein convertase subtilisin/kexin type 9, or polypeptide that specifically binds to amyloid beta). also disclosed are dimeric proteins comprising first and second apoa-1 fusion polypeptides as disclosed herein. the fusion polypeptides and dimeric proteins are useful in methods for therapy.

Inventor(s): Martha S. Hayden-Ledbetter, Jeffrey A. Ledbetter

CPC Classification: C07K14/775 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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