Combination Therapy with Gold Controlled Transgenes

Abstract: control devices are disclosed including rna destabilizing elements (rde) combined with transgenes, including chimeric antigen receptors (cars) in eukaryotic cells. these rdes can be used to optimize expression of transgenes, e.g., cars, in the eukaryotic cells so that, for example, effector function is optimized. cars and transgene payloads can also be engineered into eukaryotic cells so that the transgene payload is expressed and delivered at desired times from the eukaryotic cell. such car t-cells with transgene payloads can be combined with the administration of other molecules, e.g., other therapeutics such as anticancer therapies.

Inventor(s): Benjamin Wang, Scott Dylla, Gusti Zeiner

CPC Classification: C07K14/7155 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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