METHODS OF CHARACTERIZING AND PURIFYING VEGF RECEPTOR FUSION PROTEIN

Abstract: anti-vegf proteins including the vegf trap protein aflibercept can be produced to have a low level of an aspartyl protease (e.g., a low level of cathepsin d), such as less than 1 ppm of the aspartyl protease.

Inventor(s): Shunhai WANG, Sisi ZHANG, Yuetian YAN, Tyler GREER, Siobhan HOGAN, Xiaojing ZHENG, Hui XIAO, Ning LI, Lili GUO, Yuan MAO, Prerana MANTRI, Evan KOUFOS, Kathir MUTHUSAMY, Nisha PALACKAL, Erica PYLES

CPC Classification: C07K14/71 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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