20250206759. Fus (CHENGDU HYPERWAY PHARMACEUTICALS ., .)
FUSED RING COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE OF FUSED RING COMPOUND
Abstract: the present invention relates to the technical field of medicines, and provides a fused ring compound, a pharmaceutical composition containing the same, and use of the fused ring compound. the compound has a structure as shown in formula (i), or a tautomer, a mesomer, a racemat, an enantiomer, a diastereoisomer or a mixture thereof, a metabolite, a metabolic precursor, an isotope substitution form, a pharmaceutically acceptable salt, a hydrate, a solvate, a polymorph or a cocrystal thereof. the compound provided by the present invention can be used for treating cancers caused by kras mutation. the cancers caused by kras mutation are selected from one or more cancers caused by kras g12c, kras g12v, kras g12a and g12d mutations. in particular, the compound can serve as a g12d inhibitor and has relatively high inhibitory activity.
Inventor(s): Junfeng REN, Guanfeng LIU, Xiancai WU, Shai LI, Zhiquan SONG, Shoubing YI, Guoqing ZHUO, Lin CHEN, Chenguang YUAN, Yingfu LI
CPC Classification: C07D519/00 (HETEROCYCLIC COMPOUNDS (macromolecular compounds ))
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- Patent Applications
- CHENGDU HYPERWAY PHARMACEUTICALS CO., LTD.
- CPC C07D519/00
- Junfeng REN of Chengdu, Sichuan CN
- Guanfeng LIU of Chengdu, Sichuan CN
- Xiancai WU of Chengdu, Sichuan CN
- Shai LI of Chengdu, Sichuan CN
- Zhiquan SONG of Chengdu, Sichuan CN
- Shoubing YI of Chengdu, Sichuan CN
- Guoqing ZHUO of Chengdu, Sichuan CN
- Lin CHEN of Chengdu, Sichuan CN
- Chenguang YUAN of Chengdu, Sichuan CN
- Yingfu LI of Chengdu, Sichuan CN