PRMT5 INHIBITING COMPOUNDS AND USES THEREOF

Abstract: the present application provides novel prmt5 and/or mta-cooperative prmt5 inhibiting compounds, or pharmaceutically acceptable salts thereof. the present application also provides pharmaceutical compositions comprising one or more of the compounds, or pharmaceutically acceptable salts thereof as an active ingredient, and the use of the compounds, or pharmaceutically acceptable salts thereof in the treatment of diseases or disorders, including cancers.

Inventor(s): Ming ZHANG, Ya KONG, Lulu JIANG, Bin JIANG, Guoqiang DAI, Yulong HE, Bing HOU, Bo SHAN, Jay MEI

CPC Classification: C07D487/04 (Ortho-condensed systems)

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