METHOD FOR FORMING AMINOTHIAZOLE DERIVATIVES WITH SUPER-PARAMAGNETIC NANOPARTICLE CATALYST

Abstract: a method of making a pyrazole compound includes mixing a diazonium salt with a reactant in the presence of a solvent, thereby coupling a diazo group of the diazonium salt to an a-carbon atom of the reactant to form a reaction intermediate having a formula of (i) or (ii); mixing the reaction intermediate and hydrazine in the presence of a superparamagnetic iron oxide nanoparticles catalyst thereby cyclizing the hydrazine with an ester group of the reaction intermediate to form the pyrazole compound having a formula of (iii) or (iv).

Inventor(s): Samar A. ABUBSHAIT, Haya A. ABUBSHAIT, Sara Nabil SHABAN, Asma Mohmmad ELSHARIF, Hamad M. ALKAHTANI, Fadilah Sfouq ALEANIZY, M. Nasiruzzaman SHAIKH

CPC Classification: C07D277/50 (Nitrogen atoms bound to hetero atoms)

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