ZWITTERIONIC POLYMER COATING WITH SURFACE GRAFT CROSSLINKING, PREPARATION METHOD AND APPLICATION THEREOF

Abstract: a zwitterionic polymer coating with surface grafting crosslinking, its preparation method and application are disclosed, which relate to surface modification of biomedical materials, pipelines and other medical equipment, such as extracorporeal blood circulation devices, artificial blood vessels, catheters, endoscopes and other medical equipment, to provide functions such as anticoagulation and anti-biological adhesion. the disclosure constructs the zwitterionic polymer coating with simple process and excellent performance by simulating the structure of the blood vessel intima, having the surface micro-nano structure similar to the blood vessel intima, extremely low friction coefficient, soft elasticity and super hydrophilicity, realizing zero activation and zero adhesion of blood platelets, further providing the blood circulation effect of “blood undisturbed”, which is beneficial to avoiding the problems of thrombus of artificial blood vessels in vivo, various complications caused by clinical blood extracorporeal circulation and the like, and has great clinical application value.

Inventor(s): Shuangyang LI, Anjie DONG, Jianhua ZHANG, Yiqun ZHANG, Lingyuan LIU

CPC Classification: A61L33/0088 (Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment)

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