20250205369. Dendrimer Composi (THE JOHNS HOPKINS UNIVERSITY)
DENDRIMER COMPOSITIONS AND USE IN TREATMENT OF NEUROLOGICAL AND CNS DISORDERS
Abstract: a dendrimer formulation, such as a pamam dendrimer or a multiarm peg polymeric formulation has been developed for systemic administration to the brain or central nervous system. in the preferred embodiment, the dendrimers are in the form of dendrimer nanoparticles comprising poly(amidoamine)(pamam) hydroxyl-terminated dendrimers covalently linked to at least one therapeutic, prophylactic or diagnostic agent for treatment of one or more symptoms of neurodegenerative, neurodevelopmental or neurological disorders such as rett syndrome of autism spectrum disorders. d6 generation dendrimers provide significantly enhanced uptake into areas of brain injury, providing a means for diagnosis as well as drug delivery.
Inventor(s): Kannan RANGARAMANUJAM, Sujatha KANNAN, Elizabeth NANCE, Mary E. BLUE, Michael V. JOHNSTON, William BAUMGARTNER, Fan ZHANG, Mary Ann WILSON, Barbara SLUSHER
CPC Classification: A61K49/0054 (Preparations for testing in vivo)
Search for rejections for patent application number 20250205369
- Patent Applications
- THE JOHNS HOPKINS UNIVERSITY
- CPC A61K49/0054
- Kannan RANGARAMANUJAM of Highland MD US
- Sujatha KANNAN of Highland MD US
- Elizabeth NANCE of Baltimore MD US
- Mary E. BLUE of Baltimore MD US
- Michael V. JOHNSTON of Baltimore MD US
- William BAUMGARTNER of Ruxton MD US
- Fan ZHANG of Baltimore MD US
- Mary Ann WILSON of Columbia MD US
- Barbara SLUSHER of Kingsville MD US