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20250205352. Compositions Methods (Eli Lilly and)

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COMPOSITIONS AND METHODS FOR MODULATING NaV1.8

Abstract: the present disclosure is related to oligonucleotides, antibody-sirna conjugates, or pharmaceutical compositions thereof for inhibiting the expression of nav1.8 gene and methods of using such oligonucleotides, antibody-sirna conjugates, or pharmaceutical compositions thereof in reducing/treating pain or diseases/disorders related to nav1.8.

Inventor(s): Jeffrey BOYLES, Arvind BHATTACHARYA, Patricia BROWN-AUGSBURGER, Michael Caramian COCHRAN, Julian DAVIES, Wendy Loza HOBBS, Yu Yan KWAN, Jonatan MATALONGA BORREL, Jeff S. McDERMOTT, Thiago OLIVA DETANICO, Christopher Earle WALL

CPC Classification: A61K47/6807 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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