BI-FUNCTIONAL MOLECULES TO DEGRADE CIRCULATING PROTEINS

Abstract: described herein is a bi-functional compound for removing macrophage migration inhibitory factor (mif) or immunoglubin g (igg). further described herein is a pharmaceutical composition which comprise these bi-functional compounds. further described herein is a method for treating disease states and/or conditions with the compounds or the composition. the disease states and/or conditions are mediated through mif/igg or where mif/igg is a contributing factor to the development and perpetuation of diseases and/or conditions, such as autoimmune diseases and cancer, among others.

Inventor(s): David Spiegel, David Caianiello

CPC Classification: A61K47/55 (the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds)

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