FORMULATION HAVING IMPROVED ABSORBABILITY OF LOW-SOLUBLE AND/OR LOW-MEMBRANE-PERMEABLE DRUG

Abstract: the present invention provides a pharmaceutical composition comprising a drug with low solubility and/or low permeability and an ionic liquid, wherein the ionic liquid is an anion ingredient and a cation ingredient, the anion ingredient is oleic acid or isostearic acid, and the cation ingredient is selected from a cationic lipid as well as a transmucosal absorption enhancer or a gastrointestinal absorption enhancer comprising an ionic liquid, wherein the ionic liquid is an anion ingredient and a cation ingredient, the anion ingredient is oleic acid or isostearic acid, and the cation ingredient is selected from a cationic lipid.

Inventor(s): Takashi NAKAE, Yasushi MIWA, Hidetoshi HAMAMOTO, Noboru TATSUMI, Yutaka YAMAGATA

CPC Classification: A61K47/186 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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